Wiskott-Aldrich syndrome

(actually nothing to do with whisks)

WA protein defect is inherited (X linked recessive, so most are boys)

That protein is important in cytoskeletal function - which means that some cells ain't got the right skeleton

Translating into

• thrombocytopenia with small platelets
• Infections (low IgM and cell mediated immunity)
• eczema
• malignancies
• autoimmune diseases