Castleman's disease

rare lymphoproliferative condition

Uni-centre or multi-centre

(Uni- one node.....chop it out and the few symptoms go) (Multi- loadsa symptoms)

There is angiofollicular lymphoid hyperplasia. Two variants

• hyaline vascular
• plasma cell (even rarer!)

No known treatments

What you need to know (so you can recognise it on an MCQ in real life)

• Fever
• Hepatosplenomegaly
• Rashes, weight loss, night sweats (well, it IS lymphoproliferative)
• Polyclonal hypergammaglobulinaemia (loadsa Ig's)
• Paraneoplastic manifestations